① Reduce the single dose of levodopa/benseraside or levodopa/carbidopa per time; or appropriately add dopamine agonists or COMT inhibitors if the motor symptoms deteriorate after the dose of levodopa is reduced. ② Add amantadine (Level C evidence) [44]. ③ Add atypical neuroleptics, such as clozapine, but start with an initial low dosage and then increase gradually, and closely monitor granulocytes. ④ Replace controlled-release levodopa with immediate-release levodopa to avoid the cumulative effects of controlled-release levodopa, which can aggravate dyskinesia. |